2-Hydroxy-4-methoxybenzophenone → {4-Methoxy-2-[(prop-2-en-1-yl)oxy]phenyl}(phenyl)methanone

HRID 358382

反応式

HRID 358382 の反応式
[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[OH-].[K+].[CH2:20](Cl)[CH:21]=[CH2:22].[I-].[K+]>O1CCCC1>[CH2:22]([O:1][C:2]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5])[CH:21]=[CH2:20]

参加物

6

反応物 4

HCID 46322-Hydroxy-4-methoxybenzophenoneHCID 4875Potassium IodideHCID 7850Allyl chlorideHCID 14797Potassium Hydroxide

生成物 1

HCID 14227056{4-Methoxy-2-[(prop-2-en-1-yl)oxy]phenyl}(phenyl)methanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2-Hydroxy-4-methoxybenzophenone (114 parts) was dissolved in tetrahydrofuran (100 parts). Potassium hydroxide (30.9 parts) was added. By heating and stirring, complete dissolution was achieved. Allyl chloride (46.4 parts) and potassium iodide (4.2 parts) were added to this solution, which was then heated and refluxed for 8 hours. After cooling, it was washed with water and the solvent was removed by distillation. A crude product of the desired 2-allyloxy-4-methoxybenzophenone was obtained. It was recrystallized in n-hexane to obtain 125 parts of 2-allyloxy-4-methoxybenzophenone (melting point 40° C.) at 93% yield.

後処理

  1. temperatureBy heating
  2. dissolutioncomplete dissolution
  3. temperaturewas then heated
  4. temperaturerefluxed for 8 hours
  5. temperatureAfter cooling
  6. washit was washed with water
  7. customthe solvent was removed by distillation

出典と根拠

ORDレコード
ord-b194dbbb179640d88942b8ef085f31a9
出典データセット
uspto-grants-1984_08
特許番号
US04467082

関連ノート

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