Methyl Isocyanate → 1-(Methylcarbamoyl)-3-[(4-chlorophenyl)thio]-azacycloheptan-2-one

HRID 358438

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH:9]2[CH2:15][CH2:14][CH2:13][CH2:12][NH:11][C:10]2=[O:16])=[CH:4][CH:3]=1.[CH3:17][N:18]=[C:19]=[O:20].C([O-])(=O)CCCCCCCCCCC.C([O-])(=O)CCCCCCCCCCC.C([Sn+2]CCCC)CCC>C1(C)C=CC=CC=1>[CH3:17][NH:18][C:19]([N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH:9]([S:8][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[C:10]1=[O:16])=[O:20]

参加物

実験手順

25.6 g (0.1 mol) of 3-[(4-chlorophenyl)thio]-azacycloheptan-2-one together with 5.7 g (0.1 mol) of methyl isocyanate and 100 mg of dibutyl-tin dilaurate in 150 ml of absolute toluene are boiled under reflux for 5 hours. After the mixture has cooled, the solvent is stripped off in vacuo, and the oily residue is used for further reactions.

後処理

temperatureunder reflux for 5 hours
temperatureAfter the mixture has cooled

出典と根拠

ORDレコード: ord-7067370980904d529ab71b7ad55b6b99
出典データセット: uspto-grants-1984_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04468392

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート