4-Aminopyridine → 4-Pyridylcarbamoyl-beta-alanine ethyl ester
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[N-:8]=[C:9]=[O:10].[CH2:11]([O:13][C:14](=[O:18])[CH2:15][CH2:16]N)[CH3:12]>C(#N)C>[CH2:11]([O:13][C:14](=[O:18])[CH2:15][CH2:16][NH:8][C:9](=[O:10])[NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1)[CH3:12]参加物
4
実験手順
A solution of 1 g (10.64 mmol) of 4-aminopyridine and 2.3 g (15.9 mmol) of beta-alanine ethyl ester isocyanate in 30 ml of anhydrous acetonitrile is agitated for 20 hr at room temperature. After concentration to dryness and trituration of the resulting oily residue in ether (4 × 20 ml), 2.5 g (yield 88%) of 4-pyridylcarbamoyl-beta-alanine ethyl ester is obtained in the form of a solid having a melting point of 95° C.
後処理
- concentrationAfter concentration to dryness and trituration of the resulting oily residue in ether (4 × 20 ml)
出典と根拠
- ORDレコード
- ord-87a00d5218a444b7b0b074f246b5a9f8
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US04997667
反応ノート
読み込み中…