2-Butenoic acid, 3-amino-, ethyl ester → Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate

HRID 358588

反応式

HRID 358588 の反応式
[C:1]1(/[CH:7]=[CH:8]/[CH:9]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]([CH3:19])=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>C(O)C.N1CCCCC1>[CH3:19][C:12]1[NH:11][CH:9]=[CH:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:13]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15]

参加物

5

反応物 2

HCID 953082-Butenoic acid, 3-amino-, ethyl esterHCID 637511Cinnamaldehyde

生成物 1

HCID 14652661Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate収率 72.3%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8082Piperidine溶媒

実験手順

(E)-3-Phenyl-2-propenal (13.8 ml, 0.11 mol) and ethyl 3-amino-2-butenoate (12.9 g, 0.1 mol) were dissolved in 150 ml of absolute ethanol containing 0.5 ml of piperidine. The mixture was heated under reflux for 18 hours followed by removal of the solvent under vacuum to yield 17.6 g of ethyl 1,4-dihydro-2-methyl-4-phenyl-3-pyridinecarboxylate as a brown viscous oil.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 18 hours
  3. customfollowed by removal of the solvent under vacuum

出典と根拠

ORDレコード
ord-42e9defa45784b289909b967b73d63bc
出典データセット
uspto-grants-1991_03
特許番号
US04997837

関連ノート

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