2-Butenoic acid, 3-amino-, ethyl ester → Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate
反応式
[C:1]1(/[CH:7]=[CH:8]/[CH:9]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]([CH3:19])=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>C(O)C.N1CCCCC1>[CH3:19][C:12]1[NH:11][CH:9]=[CH:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:13]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15]参加物
5
実験手順
(E)-3-Phenyl-2-propenal (13.8 ml, 0.11 mol) and ethyl 3-amino-2-butenoate (12.9 g, 0.1 mol) were dissolved in 150 ml of absolute ethanol containing 0.5 ml of piperidine. The mixture was heated under reflux for 18 hours followed by removal of the solvent under vacuum to yield 17.6 g of ethyl 1,4-dihydro-2-methyl-4-phenyl-3-pyridinecarboxylate as a brown viscous oil.
後処理
- temperatureThe mixture was heated
- temperatureunder reflux for 18 hours
- customfollowed by removal of the solvent under vacuum
出典と根拠
- ORDレコード
- ord-42e9defa45784b289909b967b73d63bc
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US04997837
反応ノート
読み込み中…