Hydrazine hydrate (1:1) → 7-Aminohept-5-ynoic Acid

HRID 358620ノート

反応式

HRID 358620 の反応式
O.NN.C1(=O)[N:8]([CH2:9][C:10]#[C:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])C(=O)C2=CC=CC=C12>C(O)C>[NH2:8][CH2:9][C:10]#[C:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 154705147-Phthalimidohept-5-ynoic Acid

生成物 1

HCID 200669627-Aminohept-5-ynoic Acid収率 66.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
5 °C

実験手順

Hydrazine hydrate (0.1 ml) was added to a solution of 7-phthalimidohept-5-ynoic acid (0.55 g) in ethanol (25 ml). The mixture was refluxed for 3.5 hours and then the solvent was removed under reduced pressure. The residue was suspended in water (20 ml), the pH of the solution was adjusted to 5, and the solid was collected by filtration. The filtrate was evaporated to dryness and the residue was extracted with ethanol (3×5 ml). The ethanol extracts were cooled (5° C.) and the resulting precipitate was collected to give the title compound (0.19 g) m.p. 180°-183° C.

後処理

  1. temperatureThe mixture was refluxed for 3.5 hours
  2. customthe solvent was removed under reduced pressure
  3. filtrationthe solid was collected by filtration
  4. customThe filtrate was evaporated to dryness
  5. extractionthe residue was extracted with ethanol (3×5 ml)
  6. customthe resulting precipitate was collected

出典と根拠

ORDレコード
ord-f3efc93560af4e3485c6e2496ad49052
出典データセット
uspto-grants-1991_03
特許番号
US04997847

反応ノート

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