3,4-dihydro-2H-pyran → 2-(5-Bromopentyloxy)tetrahydro-2H-pyran

HRID 358629

反応式

HRID 358629 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7].[O:8]1[CH:13]=[CH:12][CH2:11][CH2:10][CH2:9]1>P(Cl)(Cl)(Cl)=O>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][O:8]1

参加物

4

反応物 2

HCID 80803,4-dihydro-2H-pyranHCID 1187091-Pentanol, 5-bromo-

生成物 1

HCID 27869332-(5-Bromopentyloxy)tetrahydro-2H-pyran収率 52%

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride触媒

実験手順

Three drops of phosphoryl chloride were added to a stirred mixture of 5-bromopentanol (34.3 g, 205 mmol) and dihydropyran (19.0 g, 226 mmol). After standing for one hour, the mixture was fractionated. Yield 34.7 g, b.p. 102° C. (0.2 bar). Chromatography on alumina eluted with petroleum ether gave the pure title compound (25.1 g, 52% of theory) as an oil.

後処理

  1. washChromatography on alumina eluted with petroleum ether

出典と根拠

ORDレコード
ord-fd69aa4689b64c6c9ad67cbdf7ab837b
出典データセット
uspto-grants-1991_03
特許番号
US04997847

関連ノート

読み込み中…