4-(2-Bromoethyl)-3-chloro-1,3-dihydro-2H-indol-2-one → 2H-Indol-2-one, 4-(2-bromoethyl)-1,3-dihydro-
反応式
[Br:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6](Cl)[C:7](=[O:13])[NH:8]2.O.[PH2]([O-])=O.[Na+]>[Pd].O>[Br:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][C:7](=[O:13])[NH:8]2参加物
5
実験手順
4-(2'-Bromoethyl)-3-chloro-1,3-dihydro-2H-indol-2-one (23.6 g. 86 mmol), sodium hypophosphite hydrate (35 g) and 10% palladium/carbon (60% w/w wet, 2.6 g) were stirred in industrial methylated spirit (250 ml)/water (30 ml) at 80° C. The reaction was complete after 2 hours as monitored by HPLC. Inorganic components were removed by filtration and the organic solvent was removed in vaccuo. The solid residue was slurried in water (100 ml) and dried overnight to give 17.0 g (82%) of 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one.
後処理
- customInorganic components were removed by filtration
- customthe organic solvent was removed in vaccuo
- customdried overnight
出典と根拠
- ORDレコード
- ord-2813a718cc3647a98d0efbd87921e660
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US04997954
反応ノート
読み込み中…