Dimethylformamide → 4-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide

HRID 359036

反応式

HRID 359036 の反応式
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[N:7][N:8]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[N+]([NH:26][C:27](N)=[O:28])([O-])=O.CN(C)C=O>O>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([N:17]3[CH2:18][CH2:19][N:20]([C:27]([NH2:26])=[O:28])[CH2:21][CH2:22]3)=[N:7][N:8]2[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 62372NitroureaHCID 151171036-fluoro-1-phenyl-3-(1-piperazinyl)-1H-indazole

生成物 1

HCID 151171044-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide収率 73%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 4.5 g of 6-fluoro-1-phenyl-3-(1-piperazinyl)-1H-indazole, 4.3 g of nitrourea, and 75 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was recrystallized twice from toluene (one charcoal treatment) to yield 3.5 g (73%) of 4-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide, m.p. 168°-170°.

後処理

  1. temperaturewas heated on a steam bath for 15 minutes
  2. customthe resulting precipitate was recrystallized twice from toluene (one charcoal treatment)

出典と根拠

ORDレコード
ord-a52aa2785e414e96a9a2cf57086189c8
出典データセット
uspto-grants-1991_03
特許番号
US04999356

関連ノート

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