Thioglycolic Acid → 2-(Tritylthio)acetic acid

HRID 359130

反応式

HRID 359130 の反応式
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[SH:21][CH2:22][C:23]([OH:25])=[O:24]>FC(F)(F)C(O)=O>[C:7]([S:21][CH2:22][C:23]([OH:25])=[O:24])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 1133Thioglycolic AcidHCID 6457Triphenylcarbinol

生成物 1

HCID 42453062-(Tritylthio)acetic acid収率 94.4%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

This compound was synthesized by the condensation of triphenylmethanol (2.84 g, 10.8 mmoles) with mercaptoacetic acid (0.75 ml, 10.8 mmoles) in 19 ml trifluoracetic acid. The TFA was removed in vacuo, giving an orange oil, which was purified by dissolution in ether and extraction with 1 N NaOH. The aqueous phase was acidified with 6N HCl, and extracted with two 30 ml portions of ether. The ethereal phase was dried over MgSO4 and evaporated to give 3.41 g (93%) of a white solid.

後処理

  1. customThe TFA was removed in vacuo
  2. customgiving an orange oil, which
  3. customwas purified by dissolution in ether
  4. extractionextraction with 1 N NaOH
  5. extractionextracted with two 30 ml portions of ether
  6. dry with materialThe ethereal phase was dried over MgSO4
  7. customevaporated

出典と根拠

ORDレコード
ord-3491d70d6f84495783e0f1a510576c8c
出典データセット
uspto-grants-1991_03
特許番号
US04999424

関連ノート

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