Allylurea → Ethyl 2-(2-propenylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate

HRID 359277

反応式

HRID 359277 の反応式
[CH2:1]([NH:4][C:5]([NH2:7])=[O:6])[CH:2]=[CH2:3].Cl[CH:9]([C:15]([C:17]([F:20])([F:19])[F:18])=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11]>>[CH2:1]([NH:4][C:5]1[O:6][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:15]([C:17]([F:18])([F:20])[F:19])[N:7]=1)[CH:2]=[CH2:3]

参加物

3

反応物 2

HCID 11181AllylureaHCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

生成物 1

HCID 20064750Ethyl 2-(2-propenylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate収率 36.1%

実験手順

By the procedure of Example 4, 6 g (60 mmol) of allyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 18 hours. The product was separated and then recrystallized from methylcyclohexane to yield 4.77 g of a yellow solid product (m.p.=48°-49° C.) identified in Table I.

後処理

  1. customThe product was separated
  2. customrecrystallized from methylcyclohexane

出典と根拠

ORDレコード
ord-c3b9ca97a4ee47c898952b886e3f5cdb
出典データセット
uspto-grants-1991_03
特許番号
US05000775

関連ノート

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