Thionyl Chloride → HCID 20064749、化合物

HRID 359279ノート

反応式

HRID 359279 の反応式
[C:1]([NH:5][C:6]1[O:7][C:8]([C:15]([OH:17])=O)=[C:9]([C:11]([F:14])([F:13])[F:12])[N:10]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:20])=O>CN(C)C=O>[CH3:2][C:1]([NH:5][C:6]1[O:7][C:8]([C:15]([Cl:20])=[O:17])=[C:9]([C:11]([F:14])([F:13])[F:12])[N:10]=1)([CH3:4])[CH3:3]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 15812073HCID 15812073、化合物

生成物 1

HCID 20064749HCID 20064749、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

By the procedure of Example 27, 17 g (64.5 mmol) of 2-(tert-butylamino)-4-trifluoromethyl-5-oxazolecarboxylic acid, 67 ml thionyl chloride and 4 of drops dimethylformamide were reacted together. The product was separated and then distilled to yield 17.2 g of a yellow solid product (m.p.=52°-60° C.; b.p. 70° C. @ 0.25 mm Hg) identified in Table I.

後処理

  1. customThe product was separated
  2. distillationdistilled

出典と根拠

ORDレコード
ord-3f5b19ad54034452bb000a87a1633a77
出典データセット
uspto-grants-1991_03
特許番号
US05000775

反応ノート

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