Tert-Butylamine → HCID 20064740、化合物

HRID 359287ノート

反応式

HRID 359287 の反応式
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].Cl[C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[C:10]([C:12]([F:15])([F:14])[F:13])[N:11]=1>C(#N)C>[CH3:2][C:1]([NH:5][C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[C:10]([C:12]([F:14])([F:13])[F:15])[N:11]=1)([CH3:4])[CH3:3]

参加物

4

反応物 2

HCID 6385Tert-ButylamineHCID 91715Flurazole

生成物 1

HCID 20064740HCID 20064740、化合物収率 42.6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

By the procedure of Example 39, a stirred mixture of 15 ml of acetonitrile, 2.72 g (38 mmol) of tert-butylamine, and 6 g (19 mmol) of benzyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506), was heated at reflux for 66 hours. The product was separated and then recrystallized from hexane to yield 2.90 g of an off-white powder product (m.p.=79°-81° C.) identified in Table I.

後処理

  1. customprepared
  2. temperature4,199,506), was heated
  3. temperatureat reflux for 66 hours
  4. customThe product was separated
  5. customrecrystallized from hexane

出典と根拠

ORDレコード
ord-3b354d60647e49aba91fd559100fef17
出典データセット
uspto-grants-1991_03
特許番号
US05000775

反応ノート

読み込み中…