Allyl bromide → HCID 13298915、化合物

HRID 359497ノート

反応式

HRID 359497 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][C:7](=[O:13])[CH:6]=[CH:5]2.C([O-])([O-])=O.[K+].[K+].[CH2:20](Br)[CH:21]=[CH2:22]>CC(C)=O>[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH2:22][CH:21]=[CH2:20])[O:8][C:7](=[O:13])[CH:6]=[CH:5]2

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 54129132H-1-Benzopyran-2-one, 7-hydroxy-6-methyl-

生成物 1

HCID 13298915HCID 13298915、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 6-methyl-7-hydroxycoumarin (I) (14.5 g), anhydrous K2CO3 (5 g), allyl bromide (15 ml) and acetone (400 ml) was refluxed for 12 h under stirring. From the refluxed mixture the solid was filtered and washed several times with acetone. The acetonic solution and the pooled washings were concentrated to dryness and the residue crystallized from MeOH, yielding 6-methyl-7-allyloxycoumarin (IV) (11.4 g; m.p. 124°-5° C.). ##STR10##

後処理

  1. temperaturewas refluxed for 12 h
  2. filtrationFrom the refluxed mixture the solid was filtered
  3. washwashed several times with acetone
  4. concentrationThe acetonic solution and the pooled washings were concentrated to dryness
  5. customthe residue crystallized from MeOH

出典と根拠

ORDレコード
ord-1ad8c1e128114636b8e0cdfb891a0a9c
出典データセット
uspto-grants-1991_03
特許番号
US05001147

反応ノート

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