N,N-Diethylaniline → HCID 13298918、化合物

HRID 359498ノート

反応式

HRID 359498 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12]CC=C)[O:8][C:7](=[O:16])[CH:6]=[CH:5]2.CCN([C:22]1[CH:23]=CC=C[CH:27]=1)CC>CCCCCC>[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:23][CH:22]=[CH2:27])[C:11]=1[OH:12])[O:8][C:7](=[O:16])[CH:6]=[CH:5]2

参加物

4

反応物 2

HCID 7061N,N-DiethylanilineHCID 13298915HCID 13298915、化合物

生成物 1

HCID 13298918HCID 13298918、化合物

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

A solution of 6-methyl-7-hydroxycoumarin (IV) (11.4 g) in diethylaniline (80 ml) was refluxed for 2 h. After cooling the solution was diluted with n-hexane (500 ml) yielding a precipitate, which was collected by filtration, washed several times with n-hexane and crystallized from EtOAc, yielding 6-methyl-7-hydroxy-8-allylcoumarin (VII) (6.3 g; m.p. 161°-2° C.). ##STR13##

後処理

  1. temperatureAfter cooling the solution
  2. customyielding a precipitate, which
  3. filtrationwas collected by filtration
  4. washwashed several times with n-hexane
  5. customcrystallized from EtOAc

出典と根拠

ORDレコード
ord-4cac852744dd4a519f4bc27ce8199bf5
出典データセット
uspto-grants-1991_03
特許番号
US05001147

反応ノート

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