Ethanolamine → N-(2-hydroxyethyl)nicotinamide

HRID 359883

反応式

HRID 359883 の反応式
[NH2:1][CH2:2][CH2:3][OH:4].[C:5](OCC)(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[N:8][CH:7]=1>>[OH:4][CH2:3][CH2:2][NH:1][C:5]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[O:12]

参加物

3

反応物 2

HCID 700EthanolamineHCID 69188Ethyl Nicotinate

生成物 1

HCID 72663N-(2-hydroxyethyl)nicotinamide収率 64.5%

実験手順

A neat mixture of 2-aminoethanol (6.1 g, 0.10 mol) and ethyl nicotinate (15.1 g, 0.10 mol) was refluxed overnight. As the mixture was cooled to room temperature, the product precipitated as a crystalline solid. It was filtered, washed with ether and then recrystallized from 2-propanol/ether. The final product was collected by vacuum filtration and washed with ether. The dried, white compound weighed 10.7 g, resulting in a 64.5% yield; mp 88.5°-89.5° C. (lit. value 92° C.).

後処理

  1. temperaturewas refluxed overnight
  2. customthe product precipitated as a crystalline solid
  3. filtrationIt was filtered
  4. washwashed with ether
  5. customrecrystallized from 2-propanol/ether
  6. filtrationThe final product was collected by vacuum filtration
  7. washwashed with ether
  8. customresulting in a 64.5% yield
  9. custommp 88.5°-89.5° C. (lit. value 92° C.)

出典と根拠

ORDレコード
ord-3712d954fac542b6ac570c680ac34ead
出典データセット
uspto-grants-1991_03
特許番号
US05002935

関連ノート

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