Phosgene → 5-Methylbenzimidazol-2-one

HRID 359900

反応式

HRID 359900 の反応式
[C:1](Cl)(Cl)=[O:2].[CH3:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]([NH2:13])[CH:7]=1.[OH-].[Na+]>O>[CH3:5][C:6]1[CH:11]=[CH:10][C:9]2=[N:12][C:1](=[O:2])[N:13]=[C:8]2[CH:7]=1

参加物

5

反応物 3

HCID 6371PhosgeneHCID 103323,4-DiaminotolueneHCID 14798Sodium Hydroxide

生成物 1

HCID 200643865-Methylbenzimidazol-2-one収率 98.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

53 g (0.54 mol) of phosgene are passed into 61 g (0.5 mol) of 4-methyl-1,2-diaminobenzene in 450 ml of water and the pH is simultaneously kept constant at 7.2 with 86 g (1.08 mol) of 50% strength aqueous sodium hydroxide solution. After cooling, 72 g of precipitated 5-methyl-benzimidazol-2-one of melting point 290° C. are obtained, which corresponds to a yield of 97% of theory.

後処理

  1. temperatureAfter cooling

出典と根拠

ORDレコード
ord-ff9a0e377a6e4b9ea13ba3f899a87854
出典データセット
uspto-grants-1991_03
特許番号
US05003079

関連ノート

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