Anisole → HCID 178503585、化合物

HRID 359928ノート

反応式

HRID 359928 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[CH:11][CH:12]=1)[N:7]=[C:8](C)[N:9]=2.[C:13]1(OC)C=CC=CC=1.[F:21][C:22]([F:29])([F:28])[S:23]([O:26]C)(=[O:25])=[O:24]>C(OCC)(=O)C>[F:21][C:22]([F:29])([F:28])[S:23]([O-:26])(=[O:25])=[O:24].[CH3:13][N:7]1[C:6]2=[CH:11][CH:12]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]2=[NH+:9][CH:8]1[S:23][CH3:22]

参加物

5

反応物 3

HCID 7519AnisoleHCID 9526Methyl triflateHCID 20064366HCID 20064366、化合物

生成物 1

HCID 178503585HCID 178503585、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

27 g of 6-methyl-2-methylcycloheptimidazole was added to 100 ml of anisole and stirred under cooling with ice. Next, 28 g of methyl trifluoromethanesulfonate was dropwise added and further everything was stirred under cooling with ice. After everything was stirred for 1 hour at room temperature, 200 ml of ethyl acetate was added, and the crystals precipitated were separated by filtration and dried.

後処理

  1. temperatureunder cooling with ice
  2. stirringfurther everything was stirred
  3. temperatureunder cooling with ice
  4. stirringAfter everything was stirred for 1 hour at room temperature
  5. customthe crystals precipitated
  6. customwere separated by filtration
  7. customdried

出典と根拠

ORDレコード
ord-372a23129d09481db7728c198ba66752
出典データセット
uspto-grants-1991_03
特許番号
US05003077

反応ノート

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