Hydrochloric Acid → Furaneol

HRID 36058

反応式

HRID 36058 の反応式
[OH-].[Na+].[CH3:3][C:4]1[O:8][C:7]([C:9](OCC)=O)=[C:6]([OH:14])[C:5]=1[OH:15].CBr.Cl>O>[CH3:3][CH:4]1[C:5](=[O:15])[C:6]([OH:14])=[C:7]([CH3:9])[O:8]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6323Methyl BromideHCID 14798Sodium HydroxideHCID 54719681Ethyl 5-methyl-3,4-dihydroxy-2-furoate

生成物 1

HCID 19309Furaneol収率 81.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of 48 g of sodium hydroxide and 37.2 g of ethyl 5-methyl-3,4-dihydroxy-2-furoate of 98.4% purity in 225 ml of water was allowed to stand at room temperature for 40 hours. The mixture was diluted with 200 g of water and 22.8 g of gaseous methyl bromide was added with stirring over a period of one hour at room temperature followed by an additional stirring period of two hours. The pH of the solution was adjusted to 5 by the addition of concentrated hydrochloric acid solution. Extraction with methyl t-butyl ether yielded 21.5 9 of 2,5-dimethyl-4-hydroxy-3[2H] furanone of 95.3% purity (molar yield 81.4%).

後処理

  1. additionwas added
  2. stirringan additional stirring period of two hours
  3. extractionExtraction with methyl t-butyl ether

出典と根拠

ORDレコード
ord-0e774a8b21704e8588d5eb566a51ada1
出典データセット
uspto-grants-1995_05
特許番号
US05412121

関連ノート

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