HCID 19939760、化合物 → 7-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']-biphenyl-4-yl]methyl-6-[(1-oxobutyl)amino]-3H-imidazo[4,5-b]pyridine

HRID 36115ノート

反応式

HRID 36115 の反応式
[CH3:1][C:2]1[C:7]([NH:8][C:9](=[O:13])[CH2:10][CH2:11][CH3:12])=[CH:6][N:5]=[C:4]2[N:14]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[S:33]([NH:36]C(C)(C)C)(=[O:35])=[O:34])=[CH:23][CH:22]=3)[C:15]([CH2:17][CH2:18][CH3:19])=[N:16][C:3]=12>FC(F)(F)C(O)=O>[CH3:1][C:2]1[C:7]([NH:8][C:9](=[O:13])[CH2:10][CH2:11][CH3:12])=[CH:6][N:5]=[C:4]2[N:14]([CH2:20][C:21]3[CH:22]=[CH:23][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[S:33]([NH2:36])(=[O:35])=[O:34])=[CH:25][CH:26]=3)[C:15]([CH2:17][CH2:18][CH3:19])=[N:16][C:3]=12

参加物

3

反応物 1

HCID 19939760HCID 19939760、化合物

生成物 1

HCID 199397527-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']-biphenyl-4-yl]methyl-6-[(1-oxobutyl)amino]-3H-imidazo[4,5-b]pyridine

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 7-methyl-2-propyl-3-[2'-(N-tert-butylaminosulfonyl)[1,1']-biphenyl-4-yl]methyl-6-[(1-oxobutyl)amino]-3H-imidazo[4,5-b]pyridine. (516 mg) in trifluoroacetic acid (30 mL) was stirred at r.t. for 12 h. The mixture was concentrated, dissolved in CH2Cl2 (100 mL) and washed with saturated aqueous Na2CO3. The organic extracts were dried (K2CO3) and concentrated to give the title compound as a solid.

後処理

  1. concentrationThe mixture was concentrated
  2. dissolutiondissolved in CH2Cl2 (100 mL)
  3. washwashed with saturated aqueous Na2CO3
  4. dry with materialThe organic extracts were dried (K2CO3)
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-a2f1f22e01684fa48df62b2cf663840c
出典データセット
uspto-grants-1995_05
特許番号
US05412097

反応ノート

読み込み中…