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HRID 36118作成日：2026年10月26日
7-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']-biphenyl-4-yl]methyl-6-[(1-oxobutyl)amino]-3H-imidazo[4,5-b]pyridine → 6-amino-7-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']-biphenyl-4-yl]methyl-3H-imidazo[4,5-b]pyridine
https://huagongshe.com/reaction/36118
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
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| 反応物 | 7-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']-biphenyl-4-yl]methyl-6-[(1-oxobutyl)amino]-3H-imidazo[4,5-b]pyridine | HCID 19939752 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 6-amino-7-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']-biphenyl-4-yl]methyl-3H-imidazo[4,5-b]pyridine | HCID 19939763 | — |
反応手順
A mixture of 7-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']biphenyl-4-yl]methyl-6-[(1-oxobutyl)amino]-3H-imidazo[4,5-b]pyridine (180 mg) in 10 mL of MeOH and 1 mL of conc aqueous HCl was heated to 50° C. for 30 h. The MeOH was removed in vacuo and 100 mL of CH2Cl2 was added. The mixture was washed with saturated aqueous NaHC03 (2×30 mL), dried (Na2SO4), and concentrated to give the title compound as a foam.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05412097 |
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| 出典データセット | uspto-grants-1995_05 |
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| ORD ID | ord-e97dca0464ab4c6c8b69dcbd3d005d6c |
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| 出典メモ | uspto-grants-1995_05 |
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