反应详情

温度

50 °C

A mixture of 7-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']biphenyl-4-yl]methyl-6-[(1-oxobutyl)amino]-3H-imidazo[4,5-b]pyridine (180 mg) in 10 mL of MeOH and 1 mL of conc aqueous HCl was heated to 50° C. for 30 h. The MeOH was removed in vacuo and 100 mL of CH2Cl2 was added. The mixture was washed with saturated aqueous NaHC03 (2×30 mL), dried (Na2SO4), and concentrated to give the title compound as a foam.

1. customThe MeOH was removed in vacuo and 100 mL of CH2Cl2
2. additionwas added
3. washThe mixture was washed with saturated aqueous NaHC03 (2×30 mL)
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated