Iodine → HCID 178502596、化合物

反応式

[Mg:1].II.[Br:4][C:5]1[CH:10]=[CH:9][C:8](OC)=[CH:7][CH:6]=1.[O:13]1[CH2:17]CCC1>>[CH3:17][O:13][Mg:1][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1.[Br-:4]

参加物

反応物 4

HCID 807Iodine

HCID 77304-Bromoanisole

HCID 8028Tetrahydrofuran

HCID 5462224Magnesium

生成物 1

HCID 178502596HCID 178502596、化合物

反応条件

温度: 65 °C

実験手順

A suspension of magnesium turnings (268 g; 11.02 moles--Janssen) in tetrahydrofuran (2695 g) was heated at 65° C. under stirring and under nitrogen. Then, iodine (2.7 g) and, after 30 minutes, 4-bromoanisole (2000 g; 10.69 moles), in 1 hour, were added to the reaction mixture. At the end of the addition, the reaction mixture was kept at 75° C. for 1 hour and, then, decanted obtaining a solution of methoxyphenylmagnesiumbromide (solution A).