関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methyl chloroformate | HCID 6586 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | tert-butyl 4-[(2R)-2-cyano-7-(4-hydroxyphenyl)heptylidene]benzoate | HCID 53887099 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4'-Methoxycarbonyloxy-4-biphenylcarboxylic acid | HCID 18328408 | 95.5% |
反応手順
4'-Hydroxy-4-biphenylcarboxylic acid (3) (4 g, 18.67 mmol) and sodium hydroxide (1.64 g, 41.1 mmol) were dissolved in water (50 ml) and ethanol (98 ml) at -10° C. To the solution, methyl chloroformate (1.73 ml, 22.4 mmol) was added and the solution was maintained at -5° C. The solution was stirred for 40 minutes and a mixture of water and hydrochloric acid (1:1) was added until the solution became acidic. The solid precipitate was collected by vacuum filtration, washed several times with distilled water and dried to yield 4.72 g (yield 95.5%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05412144 |
|---|
| 出典データセット | uspto-grants-1995_05 |
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| ORD ID | ord-233f26ba77eb48bab15e0c1b95234adc |
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| 出典メモ | uspto-grants-1995_05 |
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