反应详情

温度

-5 °C

4'-Hydroxy-4-biphenylcarboxylic acid (3) (4 g, 18.67 mmol) and sodium hydroxide (1.64 g, 41.1 mmol) were dissolved in water (50 ml) and ethanol (98 ml) at -10° C. To the solution, methyl chloroformate (1.73 ml, 22.4 mmol) was added and the solution was maintained at -5° C. The solution was stirred for 40 minutes and a mixture of water and hydrochloric acid (1:1) was added until the solution became acidic. The solid precipitate was collected by vacuum filtration, washed several times with distilled water and dried to yield 4.72 g (yield 95.5%) of the title compound.

1. customat -10° C
2. additionwas added until the solution
3. filtrationThe solid precipitate was collected by vacuum filtration
4. washwashed several times with distilled water
5. customdried