Phosphorus tribromide → 6-(Bromomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine

HRID 361408ノート

反応式

HRID 361408 の反応式
[NH2:1][C:2]1[N:3]=[C:4]([NH2:14])[C:5]2[N:11]=[C:10]([CH2:12]O)[CH:9]=[CH:8][C:6]=2[N:7]=1.P(Br)(Br)[Br:16]>C1COCC1>[NH2:1][C:2]1[N:3]=[C:4]([NH2:14])[C:5]2[N:11]=[C:10]([CH2:12][Br:16])[CH:9]=[CH:8][C:6]=2[N:7]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 13345225(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methanol

生成物 1

HCID 133452266-(Bromomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A suspension of 0.72 g (3.77 mmol) of 6 in 12 mL dry THF was stirred for 8 hours with 1 mL of phosphorus tribromide. The precipitated solid was filtered, washed with cold 50% THF-Ether, and dried to give 7. Because of the instability, this compound was not purified further. The 1HNMR showed that the majority of the solid was the desired compound.

後処理

  1. filtrationThe precipitated solid was filtered
  2. washwashed with cold 50% THF-Ether
  3. customdried
  4. customto give 7
  5. customBecause of the instability, this compound was not purified further

出典と根拠

ORDレコード
ord-e093bf24f1634bac8f07d61b20fb14a8
出典データセット
uspto-grants-1999_02
特許番号
US05866580

反応ノート

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