Water → 1-(8,9-Dihydroxynonyl)-3,7-dimethylxanthine

HRID 361491

反応式

HRID 361491 の反応式
[CH2:1]([N:10]1[C:19](=[O:20])[C:18]2[N:17]([CH3:21])[CH:16]=[N:15][C:14]=2[N:13]([CH3:22])[C:11]1=[O:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH:8]=[CH2:9].C[N+]1([O-])CC[O:27]CC1.[OH2:31].S(S([O-])=O)([O-])=O.[Na+].[Na+]>C(O)(C)(C)C.CC(C)=O>[OH:31][CH:8]([CH2:9][OH:27])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:1][N:10]1[C:19](=[O:20])[C:18]2[N:17]([CH3:21])[CH:16]=[N:15][C:14]=2[N:13]([CH3:22])[C:11]1=[O:12]

参加物

7

反応物 4

HCID 962WaterHCID 24489Sodium DithioniteHCID 82029Methyl morpholine oxideHCID 152306351-(8-Nonenyl)-3,7-dimethylxanthine

生成物 1

HCID 98408081-(8,9-Dihydroxynonyl)-3,7-dimethylxanthine収率 54%

試薬・触媒・溶媒 2

HCID 6386tert-Butanol触媒HCID 180Acetone溶媒

実験手順

A solution of 1-(8-nonenyl)-3,7-dimethylxanthine (810 mg, 2.7 mmol), 4-methylmorpholine-N- oxide (340 mg, 2.9 mmol) and 2.5% oxmium tetroxide in t-butanol (3 drops) in acetone (20 mL) and water (20 mL) was stirred for 24 hours. Saturated aqueous sodium dithionite solution (5 mL) was added. After stirring for 15 minutes, the reaction was extracted with 25% ethanol-dichloromethane (4×50 mL). The combined organic portions were dried over sodium sulfate, and the solvents were evaporated under vacuum. The solid residue was recrystallized (ethanol-chloroform), yielding 490 mg (54%) 1-(8,9-dihydroxynonyl)-3,7-dimethylxanthine (inventive compound no. 1561).

後処理

  1. extractionthe reaction was extracted with 25% ethanol-dichloromethane (4×50 mL)
  2. dry with materialThe combined organic portions were dried over sodium sulfate
  3. customthe solvents were evaporated under vacuum
  4. customThe solid residue was recrystallized (ethanol-chloroform)

出典と根拠

ORDレコード
ord-62b5b1e8145b4eb698ed85aabb6b869f
出典データセット
uspto-grants-1999_02
特許番号
US05866576

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