1-Benzyl-4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)amino]methylpiperidine → 4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine

HRID 361849ノート

反応式

HRID 361849 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]([CH2:25][CH3:26])[C:16]2[C:21]([NH:22][CH2:23][CH3:24])=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[CH2:25]([N:15]([CH2:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:16]1[C:21]([NH:22][CH2:23][CH3:24])=[CH:20][CH:19]=[CH:18][N:17]=1)[CH3:26]

参加物

5

反応物 2

HCID 543163461-Benzyl-4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)amino]methylpiperidineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 542336454-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

1-Benzyl-4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine (EXAMPLE 187, 2.38, 6.75 mmol) and palladium hydroxide on carbon (1.5 g) in 100 ml ethanol is hydrogenated under 40 p.s.i. hydrogen for 42 hr. Filtration and evaporation of the solvent gives 4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine.

後処理

  1. filtrationFiltration and evaporation of the solvent

出典と根拠

ORDレコード
ord-4d06c99cc1834823830127c4970f4dd3
出典データセット
uspto-grants-1999_02
特許番号
US05866589

反応ノート

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