1-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine → 4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine

HRID 361852ノート

反応式

HRID 361852 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:25][CH3:26])[C:15]2[C:20]([NH:21][CH2:22][CH2:23][CH3:24])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[CH2:25]([N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15]1[C:20]([NH:21][CH2:22][CH2:23][CH3:24])=[CH:19][CH:18]=[CH:17][N:16]=1)[CH3:26]

参加物

5

反応物 2

HCID 675767231-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 108253984-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

1-Benzyl-4-[N-ethyl-N-(3-propylamino-2-pyridinyl)amino]piperidine (EXAMPLE 191, 4.34 g, 12.3 mmol) and palladium hydroxide on carbon (2.0 g) in 50 ml ethanol is hydrogenated at 40 p.s.i. hydrogen for 40 hr. Filtration and removal of the solvent gives the title compound, NMR (400 MHz, CDCl3) 7.72, 6.95, 6.83, 3.72, 3.42, 3.09, 2.87, 2.00, 1.66, 1.24, 1.00 and 0.87δ.

後処理

  1. filtrationFiltration and removal of the solvent

出典と根拠

ORDレコード
ord-cc6f629da7a14fefb33ddcb47bf6452b
出典データセット
uspto-grants-1999_02
特許番号
US05866589

反応ノート

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