1-Benzyl-4-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine → 4-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine

HRID 361858ノート

反応式

HRID 361858 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:24][CH3:25])[C:15]2[C:20]([NH:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[CH2:24]([N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:15]1[C:20]([NH:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=1)[CH3:25]

参加物

4

反応物 1

HCID 104972481-Benzyl-4-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine

生成物 1

HCID 107292464-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

1-Benzyl-4-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine (EXAMPLE 205, 0.41 g, 1.2 mmol) is dissolved in 20 ml of ethanol and 0.20 g of palladium hydroxide is added. The reaction is placed on a Parr hydrogenator under 40 psi for 24 hrs. Then it is filtered through diatomaceous earth and concentrated under reduced pressure to give the title compound, NMR (300 MHz, CDCl3) 7.60, 6.80, 6.67, 4.53, 3.76, 3.76, 3.15-2.95, 2.56, 1.76, 1.54, 1.12 and 0.73δ.

後処理

  1. filtrationThen it is filtered through diatomaceous earth
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d9835ac6a15f487ab3745696857ef37e
出典データセット
uspto-grants-1999_02
特許番号
US05866589

反応ノート

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