Lithium azide → [2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl azide

HRID 36187

反応式

HRID 36187 の反応式
[C:1]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:20]=[CH:19][C:18]([CH2:21]Br)=[CH:17][CH:16]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[N-:23]=[N+:24]=[N-:25].[Li+]>>[C:1]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:23]=[N+:24]=[N-:25])=[CH:17][CH:16]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 88163Lithium azideHCID 15282100[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl bromide

生成物 1

HCID 10427616[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl azide収率 74%

実験手順

Reaction of [2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl bromide (from Step D) with lithium azide was carried out according to the procedure of Example 9, Step A. The crude product was purified by flash chromatography on silica gel (elution with 10% EtOAc in hexane) to give a 74% yield of the title compound as a white solid; satisfactory purity (by TLC in 9:1 hexane-EtOAc) for use in the next step.

後処理

  1. customThe crude product was purified by flash chromatography on silica gel (elution with 10% EtOAc in hexane)

出典と根拠

ORDレコード
ord-5b582a3dfc904b129bd9856a7382c53f
出典データセット
uspto-grants-1995_05
特許番号
US05411980

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