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Water → HCID 15282102、化合物

HRID 36189
ノート
印刷プレビュー

反応式

HRID 36189 の反応式
[H-].[Na+].[CH2:3]([C:7]1[N:8]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[S:26](=[O:33])(=[O:32])[NH:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:16][CH:15]=2)[C:9](=[O:12])[NH:10][N:11]=1)[CH2:4][CH2:5][CH3:6].[CH:34](I)([CH3:36])[CH3:35].O>CN(C=O)C>[CH2:3]([C:7]1[N:8]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[S:26](=[O:32])(=[O:33])[NH:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:18][CH:19]=2)[C:9](=[O:12])[N:10]([CH:34]([CH3:36])[CH3:35])[N:11]=1)[CH2:4][CH2:5][CH3:6]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 962WaterHCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 103886375-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

生成物 1

HCID 15282102HCID 15282102、化合物収率 48.4%

試薬・触媒・溶媒 1

HCID 6228
Dimethylformamide
溶媒

実験手順

To a suspension of 54 mg (1.35 mmole) of sodium hydride (60% in oil) in 1 ml of dry DMF was added 200 mg (0.452 mmole) of 5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step G). The resulting mixture was stirred under N2 at room temperature for 2 hours. Then 270 μL (460 mg, 2.70 mmole) of isopropyl iodide was added dropwise, and the orange mixture was stirred at room temperature overnight. Next, the mixture was treated with H2O and extracted 4× with ethyl acetate. The combined organic fractions were washed with brine, dried over MgSO4, and filtered. The filtrate was concentrated in vacuo, and the residue was flash chromatographed twice on silica gel (elution with 1.5% MeOH in CH2Cl2) to yield 106 mg (48%) of the title compound; satisfactory purity by TLC in 98.5:1.5 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 485 (M+1)+.

後処理

  1. stirringthe orange mixture was stirred at room temperature overnight
  2. extractionextracted 4× with ethyl acetate
  3. washThe combined organic fractions were washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated in vacuo
  7. customchromatographed twice on silica gel (elution with 1.5% MeOH in CH2Cl2)

出典と根拠

ORDレコード
ord-e8a7d5cebe4449f08a4c95f90385911c
出典データセット
uspto-grants-1995_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05411980

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート