Water → 1-(1-Benzothiophen-3-yl)-2-bromoethan-1-one

HRID 362252ノート

反応式

HRID 362252 の反応式
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)(=[O:36])[CH3:35].O>O1CCCC1>[Br:1][CH2:35][C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)=[O:36]

参加物

5

反応物 3

HCID 962WaterHCID 143163-AcetylbenzothiopheneHCID 17977687Phenyltrimethylammonium bromide dibromide

生成物 1

HCID 27763411-(1-Benzothiophen-3-yl)-2-bromoethan-1-one収率 63.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of phenyltrimethylammonium tribromide (9.6 g) in tetrahydrofuran (20 ml) was added dropwise over 15 minutes at ambient temperature to a stirred solution of 3-acetylbenzo[b]thiophen (5 g) in tetrahydrofuran (50 ml), then the mixture was stirred at ambient temperature for 35 minutes. Water (100 ml) was added, and the resulting solid was collected by filtration, washed with water (2×50 ml) and dried in vacuo at ambient temperature to give 3-(2-bromoacetyl)benzo[b]thiophen as a white solid (2.4 g).

後処理

  1. filtrationthe resulting solid was collected by filtration
  2. washwashed with water (2×50 ml)
  3. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-e74de6196c624e248c5ab4cf967bba06
出典データセット
uspto-grants-1999_02
特許番号
US05869492

反応ノート

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