Ethanol → 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate

HRID 362253

反応式

HRID 362253 の反応式
[Br:1][CH2:2][C:3]([C:5]1[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[S:8][CH:9]=1)=[O:4].[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C([OH:22])C>C(O)(=O)C>[OH2:4].[OH2:22].[BrH:1].[S:8]1[CH:9]=[C:5]([C:3]2[N:16]3[CH2:17][CH2:18][N:14]=[C:15]3[S:19][CH:2]=2)[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]1=2

参加物

5

反応物 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 27763411-(1-Benzothiophen-3-yl)-2-bromoethan-1-one

生成物 1

HCID 687790213-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 3-(2-bromoacetyl)benzo[b]thiophen (2.39 g), 2-imidazolidinethione (0.78 g), ethanol (60 ml) and acetic acid (40 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ether (2×50 ml), and dried in vacuo at ambient temperature to give 3-(benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1 -b]thiazole monohydrobromide dihydrate as a white solid (2.96 g), m.p. 239°-240° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ether (2×50 ml)
  5. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-fd09965459ef41efa16387e585faa295
出典データセット
uspto-grants-1999_02
特許番号
US05869492

関連ノート

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