1-(1-Benzofuran-3-yl)ethan-1-one → 1-(Benzofuran-3-yl)-2-bromoethanone

HRID 362257

反応式

HRID 362257 の反応式
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[O:40][CH:41]=1)(=[O:36])[CH3:35]>O1CCCC1>[Br:1][CH2:35][C:34]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[O:40][CH:41]=1)=[O:36]

参加物

4

反応物 2

HCID 112866121-(1-Benzofuran-3-yl)ethan-1-oneHCID 17977687Phenyltrimethylammonium bromide dibromide

生成物 1

HCID 27765801-(Benzofuran-3-yl)-2-bromoethanone収率 27.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of phenyltrimethylammonium tribromide (2.47 g) in tetrahydrofuran (20 ml) was added dropwise at ambient temperature under nitrogen over 5 minutes to a stirred solution of 3-acetylbenzo[b]furan (1 g) in tetrahydrofuran (20 ml), then the mixture was stirred at ambient temperature for a further 1.5 hours, filtered, and the solvent removed in vacuo. The residue was triturated with ether, and the resulting solid was collected by filtration and dried in vacuo at ambient temperature to give 3-(2-bromoacetyl)benzo[b]furan as an off-white solid (0.25 g).

後処理

  1. filtrationfiltered
  2. customthe solvent removed in vacuo
  3. customThe residue was triturated with ether
  4. filtrationthe resulting solid was collected by filtration
  5. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-10b5b665c38b46309fa8f6f6837d9876
出典データセット
uspto-grants-1999_02
特許番号
US05869492

関連ノート

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