Sodium Hydroxide → HCID 70284941、化合物

HRID 362263ノート

反応式

HRID 362263 の反応式
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][C:7]([CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)([OH:10])[C:8](=[CH2:9])[C:4]=2[CH:3]=1.[OH-].[Na+]>ClCCl>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][CH2:9][CH:8]([C:7](=[O:10])[CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 70284478HCID 70284478、化合物

生成物 1

HCID 70284941HCID 70284941、化合物収率 97%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 5-chloro-3-methylene-2-phenoxymethyl-2,3-dihydrobenzo[b]-thiophen-2-ol (16.9 g) in dichloromethane (250 ml) was shaken vigorously for a few seconds with 5M aqueous sodium hydroxide solution (150 ml), then the organic solution was separated, washed with water (150 ml), dried (MgSO4), and the solvent removed in vacuo to leave 1-(5-chloro-2,3-dihydrobenzo[b]thiophen-3-yl)-2-phenoxyethanone as a pink solid (16.4 g) which was used without further purification.

後処理

  1. customthe organic solution was separated
  2. washwashed with water (150 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-9e35c27a97f1484c816c2e9d40480353
出典データセット
uspto-grants-1999_02
特許番号
US05869492

反応ノート

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