1-(5-Chloro-1-benzothiophen-3-yl)ethan-1-one → HCID 57175247、化合物

HRID 362265ノート

反応式

HRID 362265 の反応式
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[C:34]([C:37]1[C:38]2[CH:45]=[C:44]([Cl:46])[CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)(=[O:36])[CH3:35]>O1CCCC1>[Br:1][CH2:35][C:34]([C:37]1[C:38]2[CH:45]=[C:44]([Cl:46])[CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)=[O:36]

参加物

4

反応物 2

HCID 113901951-(5-Chloro-1-benzothiophen-3-yl)ethan-1-oneHCID 17977687Phenyltrimethylammonium bromide dibromide

生成物 1

HCID 57175247HCID 57175247、化合物収率 261.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Phenyltrimethylammonium tribromide (3.6 g) was added in portions under nitrogen over 30 minutes to a stirred suspension of 3-acetyl-5-chlorobenzo[b]thiophen (2 g) in tetrahydrofuran (25 ml), then the mixture was stirred at ambient temperature for 3 hours and filtered. The filter cake was washed with tetrahydrofuran (10 ml), then the filtrate and washings were combined, and the solvent removed in vacuo to leave 3-(2-bromoacetyl)-5-chlorobenzo[b]thiophen as a grey solid (4.2 g) which was used without purification.

後処理

  1. filtrationfiltered
  2. washThe filter cake was washed with tetrahydrofuran (10 ml)
  3. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-34adb35a169843bd94fdeadebf6e35c5
出典データセット
uspto-grants-1999_02
特許番号
US05869492

反応ノート

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