3-(4-Fluorophenyl)-2-propenoic acid → 3-(4-Fluorophenyl)propionic acid

HRID 362804

反応式

HRID 362804 の反応式
[F:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:11][CH:12]=1

参加物

4

反応物 1

HCID 980703-(4-Fluorophenyl)-2-propenoic acid

生成物 1

HCID 1363023-(4-Fluorophenyl)propionic acid収率 91%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 4-fluorocinnamic acid (300.0 g, 1.8 mol, Aldrich) and 5% palladium on carbon (9.0 g) in ethanol (3 L) was hydrogenated at atmospheric pressure and room temperature for 4.5 h. The mixture was filtered through Celite (diatomaceous earth) and the filtrate was concentrated in vacuo to give 275.1 g (91%) of 3-(4-fluorophenyl)propionic acid as a white solid: m.p., 86°-88° C.;

後処理

  1. filtrationThe mixture was filtered through Celite (diatomaceous earth)
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-9fffec0f198b4e048795124dd3fd9a26
出典データセット
uspto-grants-1999_02
特許番号
US05872118

関連ノート

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