Oxalyl chloride → (E)-2-(6-fluoro-1-indanylidene)acetyl chloride

HRID 362812ノート

反応式

HRID 362812 の反応式
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7]/[C:8]/2=[CH:11]\[C:12]([OH:14])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:18])=O>C1C=CC=CC=1>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7]/[C:8]/2=[CH:11]\[C:12]([Cl:18])=[O:14])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 70130971(E)-2-(6-fluoro-1-indanylidene)acetic acid

生成物 1

HCID 15491026(E)-2-(6-fluoro-1-indanylidene)acetyl chloride収率 100%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

An ice-cold, stirred suspension of (E)-2-(6-fluoro-1-indanylidene) acetic acid (384 mg, 2 mmol) in benzene (10 mL) was treated with oxalyl chloride (761 mg, 6 mmol) and allowed to warm to room temperature during 1.5 h. The resulting yellow solution was concentrated in vacuo to give (E)-2-(6-fluoro-1-indanylidene)acetyl chloride as a pale yellow solid (421 mg, 100%), m.p., 97°-99° C.;

後処理

  1. concentrationThe resulting yellow solution was concentrated in vacuo

出典と根拠

ORDレコード
ord-7594ebd1d633407e96e9f371e66d3997
出典データセット
uspto-grants-1999_02
特許番号
US05872118

反応ノート

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