Hydrogen Bromide → 2-Fluorophenethyl bromide

HRID 362836

反応式

HRID 362836 の反応式
[BrH:1].S(=O)(=O)(O)O.[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15]O>>[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][Br:1]

参加物

4

反応物 3

HCID 260Hydrogen BromideHCID 1118Sulfuric AcidHCID 27332962-(2-Fluorophenyl)ethan-1-ol

生成物 1

HCID 27569642-Fluorophenethyl bromide収率 99%

実験手順

To a mixture of aqueous hydrobromic acid (48%, 360 mL) and concentrated sulfuric acid (103.6 mL) at room temperature was added dropwise 2-(2-fluorophenyl)ethanol (250 g, 1.78 mol, Aldrich). The reaction mixture was refluxed for 7 h, poured onto 600 ml of ice and the mixture was extracted with diethyl ether. The diethyl ether extracts were washed successively with saturated sodium carbonate and brine. The organic phase was dried (MgSO4) and concentrated in vacuo to give 359.9 g (99%) of 2-(2-fluorophenyl)-ethylbromide as a brown oil. This product was used without further purification. NMR (CDCl3 : d 7.6-6.9 (m. 4H, ArH), 3.6 (t, 2H CH2), 3.2 (t, 2H, CH2).

後処理

  1. temperatureThe reaction mixture was refluxed for 7 h
  2. extractionthe mixture was extracted with diethyl ether
  3. washThe diethyl ether extracts were washed successively with saturated sodium carbonate and brine
  4. dry with materialThe organic phase was dried (MgSO4)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-94c84f6978a34477bbb058ea20e1f0a0
出典データセット
uspto-grants-1999_02
特許番号
US05872118

関連ノート

読み込み中…