Oxalyl chloride → 3-(4-Fluorophenyl)butyryl chloride

HRID 362858ノート

反応式

HRID 362858 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14](C)[CH2:15]C(O)=O)=[CH:10][CH:9]=1>ClCCl>[F:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:15])[CH2:1][C:2]([Cl:4])=[O:3])=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 2919153-(4-Fluorophenyl)butanoic acid

生成物 1

HCID 232936303-(4-Fluorophenyl)butyryl chloride収率 94%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
25 °C

実験手順

Oxalyl chloride (71 g, 48.8 ml, 0.560 mol, Aldrich) was added to a mixture of 3-(4-fluorophenyl)butyric acid (34 g, 0.187 mol) in 200 ml of dichloromethane at -5° C. After stirring for 20 min at this temperature, the solution was allowed to warm to 25° C. and stirring was continued for 2 h. The volatiles were removed by spin evaporation in vacuo with the addition of dichloromethane (4 ×) during concentration to give 35.1 g (94%) of 3-(4-fluorophenyl)butyryl chloride as a light yellow oil;

後処理

  1. stirringstirring
  2. waitwas continued for 2 h
  3. customThe volatiles were removed by spin evaporation in vacuo with the addition of dichloromethane (4 ×) during concentration

出典と根拠

ORDレコード
ord-4862d21e0d0649e3a1ea9ca986876ce7
出典データセット
uspto-grants-1999_02
特許番号
US05872118

反応ノート

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