Water → 1-(2-Phthalimidoethyl)-4,5-diphenylimidazole

HRID 362895ノート

反応式

HRID 362895 の反応式
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].Cl[CH2:14][CH2:15][N:16]1[C:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[C:19]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:18]=[CH:17]1.O>CN(C=O)C.C(Cl)(Cl)Cl>[C:1]1(=[O:11])[N:5]([CH2:14][CH2:15][N:16]2[C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:19]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[N:18]=[CH:17]2)[C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12

参加物

6

反応物 3

HCID 962WaterHCID 24194345Phthalimide potassium saltHCID 542225981-(2-Chloroethyl)-4,5-diphenylimidazole

生成物 1

HCID 539687861-(2-Phthalimidoethyl)-4,5-diphenylimidazole収率 73%

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6228Dimethylformamide溶媒

実験手順

Step 2): A mixture of potassium phthalimide (0.21 g, 1.1 mmol) and 1-(2-chloroethyl)-4,5-diphenylimidazole (0.32 g, 1.1 mmol) in dry DMF (10 ml) was heated at 60°-70° C. for 6 hours. The reaction mixture was cooled, diluted with chloroform, poured into water and extracted with chloroform. The organic layer was dried (MgSO4) and concentrated. The residue was purified by column chromatography on silica gel (40% ethyl acetate in chloroform) to give 1-(2-phthalimidoethyl)-4,5-diphenylimidazole (73.0%).

後処理

  1. temperaturewas heated at 60°-70° C. for 6 hours
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted with chloroform
  4. dry with materialThe organic layer was dried (MgSO4)
  5. concentrationconcentrated
  6. customThe residue was purified by column chromatography on silica gel (40% ethyl acetate in chloroform)

出典と根拠

ORDレコード
ord-b9b7c5b046e0459fb54543dbd79ec6ea
出典データセット
uspto-grants-1999_02
特許番号
US05872115

反応ノート

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