Dihydrochalcone → 1,3-Diphenylpropan-1-ol

HRID 363014

反応式

HRID 363014 の反応式
[C:1]1([CH2:7][CH2:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>C(O)C>[C:11]1([CH:9]([OH:10])[CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 64802DihydrochalconeHCID 4311764Sodium borohydride

生成物 1

HCID 2501291,3-Diphenylpropan-1-ol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

β-Phenylpropiophenone (6-1) (7.5 g, 36.0 mmol) was suspended in ethanol (100 ml) and sodium borohydride (0.68 g, 18.0 mmol) was added under N2. The resulting solution was stirred at ambient temperature overnight. The ethanol was removed in vacuo and the residual oil-solid was taken up in ethyl acetate (100 ml) and water (30 ml). The ethyl acetate layer was removed, washed with water, dried, filtered and concentrated in vacuo to give 6-2 as a colorless oil.

後処理

  1. customThe ethanol was removed in vacuo
  2. customThe ethyl acetate layer was removed
  3. washwashed with water
  4. customdried
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8f650809c4e84eedb17aac34a747ef24
出典データセット
uspto-grants-1999_02
特許番号
US05872138

関連ノート

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