Sodium Dithionite → 1,3-Di-cyclopropyl-8-amino Xanthine

HRID 3631

反応式

HRID 3631 の反応式
[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[NH:11][C:10]([N+:15]([O-])=O)=[N:9][C:8]=3[N:7]([CH:18]3[CH2:20][CH2:19]3)[C:5]2=[O:6])[CH2:3][CH2:2]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>CO.O>[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[NH:11][C:10]([NH2:15])=[N:9][C:8]=3[N:7]([CH:18]3[CH2:20][CH2:19]3)[C:5]2=[O:6])[CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 24489Sodium DithioniteHCID 98384921,3-Di-cyclopropyl-8-nitro xanthine

生成物 1

HCID 98136211,3-Di-cyclopropyl-8-amino Xanthine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

1,3-Di-cyclopropyl-8-nitro xanthine (0.4 g, 0.0014 mol) was dissolved in methanol (20 ml) and treated with a sodium dithionite solution in water (0.5 g in 5 ml) at room temperature with stirring. After stirring for three hours the solvent was removed in vacuo, the residue taken up with dichloromethane and extracted with water (40 ml).

後処理

  1. stirringAfter stirring for three hours the solvent
  2. customwas removed in vacuo
  3. extractionextracted with water (40 ml)

出典と根拠

ORDレコード
ord-6437b784cf604f0ba86ac0d067c33742
出典データセット
uspto-grants-1998_03
特許番号
US05734051

関連ノート

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