Water → 6-(2-(Trifluoromethyl)phenyl)nicotinic acid

HRID 363194ノート

反応式

HRID 363194 の反応式
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1.[Mn]([O-])(=O)(=O)=[O:19].[K+].[OH2:24]>>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:19])=[O:24])=[CH:11][N:10]=1

参加物

4

反応物 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 53975108HCID 53975108、化合物

生成物 1

HCID 247299916-(2-(Trifluoromethyl)phenyl)nicotinic acid

実験手順

A suspension of 2-(2-Trifluoromethylphenyl)-5-methylpyridine (0.40 g, 1.68 mmol) and potassium permanganate (1.60 g, 10.1 mmol), in water (10 mL) was heated at reflux for 16 hours. The reaction was filtered hot through celite to remove the solids. Acetic acid was added to the colourless filtrate to yield a pH of 5 and the resulting suspension was extracted with CH2Cl2, washed with water (10 mL), dried, (MgSO4), and the solvent evaporated in vacuo to afford the title compound.

後処理

  1. temperatureat reflux for 16 hours
  2. filtrationThe reaction was filtered hot through celite
  3. customto remove the solids
  4. additionAcetic acid was added to the colourless filtrate
  5. customto yield a pH of 5
  6. extractionthe resulting suspension was extracted with CH2Cl2
  7. washwashed with water (10 mL)
  8. dry with materialdried, (MgSO4),
  9. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-3ec0301730bb4dd5829e024c0c345dbe
出典データセット
uspto-grants-1999_02
特許番号
US05872136

反応ノート

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