3-Bromobenzoic acid → 1-Bromo-3-tert-butylbenzene

HRID 36344

反応式

HRID 36344 の反応式
[C:1]([C:5]1[CH:6]=[C:7](C#C)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[Br:13]C1C=C(C=CC=1)C(O)=O.C[Al](C)C>CCCCCC>[C:1]([C:5]1[CH:6]=[C:7]([Br:13])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 114563-Bromobenzoic acid2 回HCID 149896671-(tert-Butyl)-3-ethynylbenzene2 回HCID 16682925Trimethylaluminum

生成物 1

HCID 3437981-Bromo-3-tert-butylbenzene

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Reaction Scheme 4 discloses a specific synthetic route to 3-tert-butylphenyl ethyne (Compound 22) starting with meta bromobenzoic acid (Compound 23), which is treated with trimethylaluminum in hexane to yield 3-tert-butyl bromobenzene (Compound 24). 3-Tert-butyl bromobenzene 24 is thereafter converted into the ethyne derivative 22 through the trimethylsilyl ethyne intermediate 25 in steps similar to the steps described in connection with Reaction Scheme 3.

後処理

  1. customReaction Scheme 4

出典と根拠

ORDレコード
ord-1545945aa4924efca8fa5810dddf53f3
出典データセット
uspto-grants-1995_05
特許番号
US05414007

関連ノート

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