Tetrahydrofuran → HCID 15839665、化合物

HRID 363526ノート

反応式

HRID 363526 の反応式
[C:1]([C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:12]([CH2:13][C:14]([NH2:16])=[S:15])=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].C1COCC1.[CH3:24][N:25]1[CH:29]=[CH:28][CH:27]=[C:26]1[C:30](=O)[CH2:31]Br>CCOC(C)=O>[C:1]([C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:12]([CH2:13][C:14]3[S:15][C:30]([C:26]4[N:25]([CH3:24])[CH:29]=[CH:28][CH:27]=4)=[CH:31][N:16]=3)=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 124077412-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethan-1-oneHCID 53772023HCID 53772023、化合物

生成物 1

HCID 15839665HCID 15839665、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
50 °C

実験手順

To a 25 mL round bottomed flask with a stirring bar reflux condenser and an argon inlet is added 1-(4-cyanobenzyl)-5-(aminothiocarbonyl)methyl-1H-imidazole (0.12 g, 0.468 mmol), dry THF (10 mL), and N-methyl-a-bromoacetylpyrrole (0.098 g, 0.491 mmol). This mixture is heated at 50° C. for 7 hours. The cooled reaction mixture is diluted with EtOAc and washed sucessively with aq. NaHCO3, water, and brine. The organic extract is dried, (MgSO4) and the solvent is evaporated in vacuo. The residue is purified by chromatography to afford the title compound.

後処理

  1. temperatureTo a 25 mL round bottomed flask with a stirring bar reflux condenser and an argon inlet
  2. customThe cooled reaction mixture
  3. washwashed sucessively with aq. NaHCO3, water, and brine
  4. extractionThe organic extract
  5. customis dried
  6. custom(MgSO4) and the solvent is evaporated in vacuo
  7. customThe residue is purified by chromatography

出典と根拠

ORDレコード
ord-ec83389ff2e9450381e7f7d96dca43f4
出典データセット
uspto-grants-1999_02
特許番号
US05874452

反応ノート

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