Phosphorus tribromide → (3-Bromoprop-1-yn-1-yl)benzene

HRID 363533

反応式

HRID 363533 の反応式
P(Br)(Br)[Br:2].[C:5]1([C:11]#[C:12][CH2:13]O)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(OCC)C.N1C=CC=CC=1>[C:5]1([C:11]#[C:12][CH2:13][Br:2])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

5

反応物 2

HCID 24614Phosphorus tribromideHCID 1231153-Phenyl-2-propyn-1-ol

生成物 1

HCID 10987157(3-Bromoprop-1-yn-1-yl)benzene収率 248.9%

試薬・触媒・溶媒 2

HCID 1049Pyridine触媒HCID 3283Diethyl Ether溶媒

反応条件

温度
40 °C

実験手順

Phosphorous tribromide (2.62 mL, 27.6 mmol) was added to a solution of 3-phenyl-2-propyn-1-ol (10.0 g, 76 mmol) and pyridine (0.14 mL, 1.77 mmol) in diethyl ether (22 mL) at a rate to maintain reflux. After addition, the mixture was heated at 40° C. for 2 h. The mixture was cooled and poured onto ice. The organic layer was separated and diluted with diethyl ether (100 mL), washed with saturated sodium bicarbonate (2×50 mL) and saturated sodium chloride (50 mL). The organic layer was dried (MgSO4), filtered and concentrated in vacuo to afford 1-phenyl-3-bromo-1-propyn (13.4 g, 90%).

後処理

  1. temperatureto maintain
  2. temperaturereflux
  3. additionAfter addition
  4. temperatureThe mixture was cooled
  5. additionpoured onto ice
  6. customThe organic layer was separated
  7. additiondiluted with diethyl ether (100 mL)
  8. washwashed with saturated sodium bicarbonate (2×50 mL) and saturated sodium chloride (50 mL)
  9. dry with materialThe organic layer was dried (MgSO4)
  10. filtrationfiltered
  11. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0d66d159788a4042a1e2df1d512b3abd
出典データセット
uspto-grants-1999_02
特許番号
US05874473

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