Hydrazine → HCID 178478026、化合物
反応式
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:10][NH2:11].[N:12]([O-])=O.[Na+]>CO>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]1[NH:5][N:12]=[N:11][N:10]=1参加物
5
実験手順
First, 71.2 mmol of 2-chlorobenzonitrile was dissolved in 50 ml of methanol, and 356 mmol of hydrazine and 35.6 mmol of 28% methylate were added thereto, followed by keeping at the reflux temperature for 5 hours. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in 50 ml of 50% hydrochloric acid, and 74.8 mmol of sodium nitrite was added thereto at 0° C. to cause reaction. The reaction mixture was extracted with ethyl acetate to give 5-(2-chlorophenyl)tetrazole. Yield, 70%.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- dissolutionThe residue was dissolved in 50 ml of 50% hydrochloric acid
- customat 0° C.
- customreaction
- extractionThe reaction mixture was extracted with ethyl acetate
出典と根拠
- ORDレコード
- ord-2729a8ebc3b44161a71b83f42b3514a2
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05874593
反応ノート
読み込み中…