Formic Acid → 3-(4-Nitrophenyl)propanoic acid

HRID 36420

反応式

HRID 36420 の反応式
CC1(C)[O:9][C:7](=[O:8])[CH2:6][C:4](=O)O1.[N+:11]([C:14]1[CH:21]=[CH:20][C:17](C=O)=[CH:16][CH:15]=1)([O-:13])=[O:12].C(O)=O>C(N(CC)CC)C>[N+:11]([C:14]1[CH:21]=[CH:20][C:17]([CH2:4][CH2:6][C:7]([OH:9])=[O:8])=[CH:16][CH:15]=1)([O-:13])=[O:12]

参加物

5

反応物 3

HCID 284Formic AcidHCID 5414-NitrobenzaldehydeHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

生成物 1

HCID 855263-(4-Nitrophenyl)propanoic acid

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
105 °C

実験手順

3.60 g (0.025 mol) of Meldrum's acid and 3.8 g (0.025 mol) of p-nitrobenzaldehyde were weighed in to 25 ml of the mixture of formic acid and triethylamine prepared as described in Example l. The reaction mixture was heated to 105° C. during 1 hour and reacted at the same temperature for 1 hour. The product was isolated according to Example 1.

後処理

  1. customprepared
  2. customreacted at the same temperature for 1 hour
  3. customThe product was isolated

出典と根拠

ORDレコード
ord-34d196c1fab248819f8d6892c2587e9f
出典データセット
uspto-grants-1995_05
特許番号
US05414108

関連ノート

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