Sodium → HCID 20240529、化合物

HRID 364230ノート

反応式

HRID 364230 の反応式
[Na].[CH3:2][O-:3].[Na+].Cl[C:6]1[CH:11]=[C:10]([CH2:12][N:13]2[C:17](=[O:18])[C:16]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]3[C:14]2=[O:23])[N:9]=[C:8]([S:24][CH3:25])[N:7]=1>CO>[CH3:2][O:3][C:6]1[CH:11]=[C:10]([CH2:12][N:13]2[C:17](=[O:18])[C:16]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]3[C:14]2=[O:23])[N:9]=[C:8]([S:24][CH3:25])[N:7]=1

参加物

5

反応物 3

HCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 13377335HCID 13377335、化合物

生成物 1

HCID 20240529HCID 20240529、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 100 ml of methanol was added 1.55 g (67.4 mmole) of sodium metal to prepare 67.4 mmole of sodium methoxide. To this solution was added 20.0 g (62.6 mmole) of 4-chloro-2-methylthio-6-phthalimidomethylpyrimidine (from Example 2) and the mixture was heated at reflux for 16 hours. The mixture was cooled, and the solid was then separated by filtration. This solid was washed sequentially with methanol and water to provide 4-methoxy-2-methylthio-6-phthalimidomethylpyrimidine as a white solid. The structural assignment was confirmed by infrared and nuclear magnetic resonance spectral analyses.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 16 hours
  3. temperatureThe mixture was cooled
  4. customthe solid was then separated by filtration
  5. washThis solid was washed sequentially with methanol and water

出典と根拠

ORDレコード
ord-08c5264727eb4a5fa1be2c76da6a44ab
出典データセット
uspto-grants-1986_08
特許番号
US04604466

反応ノート

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